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Some of the most popular sex hormones used are DHEA, Testosterone, and Estradiol. All of these have different effects on sex drive and sexual performance. For example, it's possible that you're trying to increase your testosterone or DHEA level, but if that's not working, you may have low sex drive, and a higher chance of premature ejaculation. Testosterone has a negative effect on the production of erections and orgasm in most men. Anecdotally, there are reports of men who have higher testosterone levels who have better sex drive. Testosterone also affects the levels of other important hormones such as cortisol. High levels of cortisol are a sign of poor sleep and a low libido. It can also lead to weight gain and fat deposits in the abdomen. The more cortisol your body has, the higher your risk for obesity. It also causes the body to release less body fat, which can lead to a higher level of free testosterone in your body. But when a woman has low levels of testosterone, she has difficulty in having an orgasm. When her testosterone levels are low, she can also have an irregular menstrual cycle and painful periods.